Three hundred twenty patients were included in the Nordic MCL2 and MCL3 trials from 2000 to 2005 and 2005 to 2009, respectively. 3, 23 Patients were younger than 66 years, had stage II-IV MCL, and were considered fit for ASCT. Diagnostic specimens underwent central pathological review according to World Health Organization criteria.
15-year follow-up of the Second Nordic Mantle Cell Lymphoma trial (MCL2): prolonged remissions without survival plateau. Research output: Contribution to journal › Journal article › Research › peer-review
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One such strategy is the Nordic MCL2 regimen, developed by the Nordic Lymphoma Group. In 2008 we reported the early - based on the median observation time of 4 years - results of the Nordic Lymphoma Group MCL2 study of frontline intensive induction immunochemotherapy and autologous stem cell transplantation (ASCT), with more than 60% event-free survival at 5 years, and no subsequent relapses reported. In recent decades, the prognosis of Mantle Cell Lymphoma (MCL) has been significantly improved by intensified first‐line regimens containing cytarabine, rituximab and consolidation with high‐dose‐therapy and autologous stem cell transplantation. One such strategy is the Nordic MCL2 regimen, developed by the Nordic Lymphoma Group. Mantle cell lymphoma (MCL) has a poor prognosis with a median survival of 5 years based on conventional immunochemotherapy.
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Leukemia. 2016 Jun;30(6):1428-30. doi: 10.1038/leu.2015.322. Epub 2015 Nov 24. Total body irradiation after high-dose cytarabine in mantle cell lymphoma: a comparison of Nordic MCL2, HOVON-45, and European MCL Younger trials.
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doses. Protected by US Patents REAL-WORLD OUTCOME IN MANTLE CELL LYMPHOMA – A STUDY OF RELATIVE AND OVERALL SURVIVAL IN PATIENTS PRIMARILY TREATED WITH R-BENDAMUSTINE, R-CHOP OR THE NORDIC MCL2 REGIMEN IN SWEDEN 2007-2017
Nordic MCL2 Trial Update: 6-year follow-up after intensive immunochemotherapy for untreated mantle cell lymphoma followed by BEAM or BEAC Plus autologous stem-cell support: still very long
Nordic MCL2 trial update: six-year follow-up after intensive immunochemotherapy for untreated mantle cell lymphoma followed by BEAM or BEAC + autologous stem-cell support: still very long survival but late relapses do occur. Nordic MCL2 and female sex were used as reference categories.
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One such regimen was introduced by the MCL2 trial, conducted by the Nordic Lymphoma Group (NLG), and showed a projected 10-year OS and PFS of 58% and 43%, respectively, after a median follow-up time of 6.5 years (Geisler, BJH, 2012). Aims The MCL2 regimen is still the 1-st-line regimen of choice for younger patients in many centers worldwide.
maxiCHOP – cycle 1 Day Medication Dose Route NORDIC MCL PROTOCOL #. MCL1 (1997–2000). MCL2 (2000-). P value. Supported by the Nordic Cancer Union No. of Pts included/eval.